A preliminary investigation of the effects of maternal ethanol intake during gestation and lactation on brain adenosine A(1) receptor expression in rat offspring.
Identifieur interne : 005666 ( Main/Exploration ); précédent : 005665; suivant : 005667A preliminary investigation of the effects of maternal ethanol intake during gestation and lactation on brain adenosine A(1) receptor expression in rat offspring.
Auteurs : Timothy Othman [Canada] ; Dallas Legare ; Parissa Sadri ; W Wayne Lautt ; Fiona E. ParkinsonSource :
- Neurotoxicology and teratology [ 0892-0362 ]
English descriptors
- KwdEn :
- Animals, Binding, Competitive, Brain (drug effects), Brain (embryology), Brain (metabolism), Ethanol (toxicity), Female, Gene Expression Regulation, Developmental (drug effects), Lactation, Ligands, Male, Pregnancy, Prenatal Exposure Delayed Effects, RNA, Messenger (analysis), Rats, Rats, Sprague-Dawley, Receptors, Purinergic P1 (biosynthesis), Receptors, Purinergic P1 (genetics), Reverse Transcriptase Polymerase Chain Reaction.
- MESH :
- chemical , analysis : RNA, Messenger.
- chemical , biosynthesis : Receptors, Purinergic P1.
- chemical , genetics : Receptors, Purinergic P1.
- chemical , toxicity : Ethanol.
- drug effects : Brain, Gene Expression Regulation, Developmental.
- embryology : Brain.
- metabolism : Brain.
- Animals, Binding, Competitive, Female, Lactation, Ligands, Male, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Ethanol exposure during fetal development can result in behavioral and neurological deficits, including reduced cognitive functions, retarded growth, and craniofacial abnormalities. Adenosine is an endogenous neuromodulator that fine-tunes the release and/or synaptic activities of several neurotransmitters, including glutamate, dopamine, and serotonin. Our aim was to determine whether ethanol exposure during early development affects adenosine receptors, particularly the A1 receptor subtype, in adult rats. Female rats were given water or 15% (vol/vol) ethanol in water prior to mating and throughout gestation and lactation. Sixty-day-old male rat offspring from these dams were randomly selected and assayed for adenosine A1 receptor expression in four brain areas: cortex, cerebellum, hippocampus, and striatum. Our results indicate that ethanol intake by dams decreased body and brain weights of offspring and reduced both A1 receptor mRNA and protein density in cortex and cerebellum. These preliminary findings indicate that ethanol intake by dams during pregnancy and lactation can affect adenosine A1 receptor signalling in the offspring. A pair-fed controlled study is warranted to explore these findings further.
PubMed: 11943515
Affiliations:
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Le document en format XML
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Parkinson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2002 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:11943515</idno><idno type="pmid">11943515</idno><idno type="wicri:Area/PubMed/Corpus">001527</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001527</idno><idno type="wicri:Area/PubMed/Curation">001527</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001527</idno><idno type="wicri:Area/PubMed/Checkpoint">001527</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001527</idno><idno type="wicri:Area/Ncbi/Merge">000214</idno><idno type="wicri:Area/Ncbi/Curation">000214</idno><idno type="wicri:Area/Ncbi/Checkpoint">000214</idno><idno type="wicri:doubleKey">0892-0362::Othman T:a:preliminary:investigation</idno><idno type="wicri:Area/Main/Merge">006083</idno><idno type="wicri:Area/Main/Curation">005666</idno><idno type="wicri:Area/Main/Exploration">005666</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A preliminary investigation of the effects of maternal ethanol intake during gestation and lactation on brain adenosine A(1) receptor expression in rat offspring.</title><author><name sortKey="Othman, Timothy" sort="Othman, Timothy" uniqKey="Othman T" first="Timothy" last="Othman">Timothy Othman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Legare, Dallas" sort="Legare, Dallas" uniqKey="Legare D" first="Dallas" last="Legare">Dallas Legare</name></author><author><name sortKey="Sadri, Parissa" sort="Sadri, Parissa" uniqKey="Sadri P" first="Parissa" last="Sadri">Parissa Sadri</name></author><author><name sortKey="Lautt, W Wayne" sort="Lautt, W Wayne" uniqKey="Lautt W" first="W Wayne" last="Lautt">W Wayne Lautt</name></author><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name></author></analytic><series><title level="j">Neurotoxicology and teratology</title><idno type="ISSN">0892-0362</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Binding, Competitive</term><term>Brain (drug effects)</term><term>Brain (embryology)</term><term>Brain (metabolism)</term><term>Ethanol (toxicity)</term><term>Female</term><term>Gene Expression Regulation, Developmental (drug effects)</term><term>Lactation</term><term>Ligands</term><term>Male</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>RNA, Messenger (analysis)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Receptors, Purinergic P1 (biosynthesis)</term><term>Receptors, Purinergic P1 (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, Purinergic P1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Purinergic P1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Ethanol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Gene Expression Regulation, Developmental</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Binding, Competitive</term><term>Female</term><term>Lactation</term><term>Ligands</term><term>Male</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ethanol exposure during fetal development can result in behavioral and neurological deficits, including reduced cognitive functions, retarded growth, and craniofacial abnormalities. Adenosine is an endogenous neuromodulator that fine-tunes the release and/or synaptic activities of several neurotransmitters, including glutamate, dopamine, and serotonin. Our aim was to determine whether ethanol exposure during early development affects adenosine receptors, particularly the A1 receptor subtype, in adult rats. Female rats were given water or 15% (vol/vol) ethanol in water prior to mating and throughout gestation and lactation. Sixty-day-old male rat offspring from these dams were randomly selected and assayed for adenosine A1 receptor expression in four brain areas: cortex, cerebellum, hippocampus, and striatum. Our results indicate that ethanol intake by dams decreased body and brain weights of offspring and reduced both A1 receptor mRNA and protein density in cortex and cerebellum. These preliminary findings indicate that ethanol intake by dams during pregnancy and lactation can affect adenosine A1 receptor signalling in the offspring. A pair-fed controlled study is warranted to explore these findings further.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><noCountry><name sortKey="Lautt, W Wayne" sort="Lautt, W Wayne" uniqKey="Lautt W" first="W Wayne" last="Lautt">W Wayne Lautt</name><name sortKey="Legare, Dallas" sort="Legare, Dallas" uniqKey="Legare D" first="Dallas" last="Legare">Dallas Legare</name><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name><name sortKey="Sadri, Parissa" sort="Sadri, Parissa" uniqKey="Sadri P" first="Parissa" last="Sadri">Parissa Sadri</name></noCountry><country name="Canada"><region name="Manitoba"><name sortKey="Othman, Timothy" sort="Othman, Timothy" uniqKey="Othman T" first="Timothy" last="Othman">Timothy Othman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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